Causes

Psoriasis occurs when skin cells are replaced more quickly than usual. It's not known exactly why this happens, but research suggests it's caused by a problem with the immune system.

Your body produces new skin cells in the deepest layer of skin. These skin cells gradually move up through the layers of skin until they reach the outermost level, where they die and flake off. This whole process normally takes around 3 to 4 weeks.

However, in people with psoriasis, this process only takes about 3 to 7 days. As a result, cells that are not fully mature build up rapidly on the surface of the skin, causing flaky, crusty red patches covered with silvery scales.

Problems with the immune system

Your immune system is your body's defence against disease and it helps fight infection. One of the main types of cell used by the immune system is called a T-cell.

T-cells normally travel through the body to detect and fight invading germs, such as bacteria. But in people with psoriasis, they start to attack healthy skin cells by mistake.

This causes the deepest layer of skin to produce new skin cells more quickly than usual, triggering the immune system to produce more T-cells.

It's not known what exactly causes this problem with the immune system, although certain genes and environmental triggers may play a role.

Genetics

Psoriasis runs in families, so you may be more likely to get psoriasis if you have a close relative with the condition, but the exact role genetics plays in psoriasis is unclear.

Research has shown that many different genes are linked to the development of psoriasis, and it's likely that different combinations of genes may make people more vulnerable to the condition.

However, having these genes does not necessarily mean you'll develop psoriasis.

Psoriasis triggers

Many people's psoriasis symptoms start or get worse because of a certain event, called a trigger. Knowing your triggers may help you avoid a flare-up.

Common psoriasis triggers include:

• an injury to your skin, such as a cut, scrape, insect bite or sunburn – this is called the Koebner response
• drinking excessive amounts of alcohol
• smoking
• stress
• hormonal changes, particularly in women – for example, during puberty and the menopause
• certain medicines – such as lithium, some antimalarial medicines, anti-inflammatory medicines including ibuprofen, and ACE inhibitors (used to treat high blood pressure)
• throat infections – in some people, usually children and young adults, a form of psoriasis called guttate psoriasis develops after a streptococcal throat infection, but most people who have streptococcal throat infections don't develop psoriasis
• other immune disorders, such as HIV, which cause psoriasis to flare up or appear for the first time

Psoriasis is not contagious, so it cannot be spread from person to person.

Page last reviewed: Sun May 2021 Next review due: Wed Feb 2020